Advancing hypo recovery for people living with type 1 diabetes
Klario is a first-in-class hypo recovery drink combining glucose with BHB to help people feel and function better after low blood sugar.
Klario is a first-in-class hypo recovery drink combining glucose with BHB to help people feel and function better after low blood sugar.
For many people with type 1 diabetes, hypos are not occasional events — they are repeated disruptions to daily life. Standard glucose-only treatments correct blood sugar but leave many patients with rebound highs, recurrent lows, and a lingering hypo 'hangover.'
Klario® is a novel recovery drink that combines 15g of fast‑acting carbohydrate with adaptive energy sources - beta‑hydroxybutyrate and lactate.
Its proprietary multi-substrate system, MESH™, was designed to support rapid blood glucose correction and sustained brain energy recovery after a hypo.
Klario is validated through two randomized clinical studies, analyzing more than 1,000 real-world hypoglycemic episodes.
Klario was associated with higher post‑hypoglycemia Time‑in‑Range and fewer recurrent episodes versus participants' usual glucose‑only products.
Participants reported fewer “hypo hangover” symptoms, faster return to normal activities, and less severe after-effects such as brain fog and fatigue.
Clinical outcomes tell part of the story. Julia, a clinical study participant, describes what complete recovery with Klario looked like for her — and why it matters.
SHIFT (Supporting Hypoglycemia Innovation and Future Treatments) is a free membership program for diabetes care professionals. Join a growing community dedicated to improving patient outcomes in hypo management.
Access an initial supply of Klario to evaluate with your patients.
Educational sessions with leading diabetes clinicians and researchers.
Ready-to-use patient leaflets and prescribing guides.
Explore future research collaborations and help shape hypoglycemia management standards.
Receive discounts and special offers for your clinic and your patients.
Free membership for registered healthcare professionals. Takes 2 minutes to sign up.
Evidence shows that during and after a hypo, the brain's ability to convert glucose into usable energy can be temporarily impaired.
This 'bottleneck' can mean that even once blood sugar is corrected, energy supply to neurons may still lag.
The human brain can efficiently utilize alternative energy sources like beta-hydroxybutyrate and lactate, particularly during glucose scarcity.
These follow different metabolic pathways, bypassing the energy bottleneck and delivering an efficient energy supply to the brain.
Applying multi-energy substrates for hypoglycemia (MESH™) approaches may help restore blood glucose and brain energy.
Klario's MESH™ formula and research program have been developed in collaboration with leading clinicians and researchers in diabetes, metabolic medicine, and exercise physiology.
We've answered the most common clinical and practical questions on our FAQ page.